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The nicotine in these products can rewire an adolescents brain, leading to years of addiction, said Scott Gottlieb, the head of the Food and Drug Administration

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This catalyst effect, supported by findings that initial E-cigarette use predicts future smoking and that product initiation correlates with increased susceptibility to other products, means that pouch use might not only establish nicotine dependence but could also serve as a gateway to initiating or maintaining the use of other, potentially more harmful, products like cigarettes or E-cigarettes (30, 31)